Can Spermidine Help Osteoporosis? Exploring the Benefits of This Natural Supplement

By Dr. Steve Bennett


Osteoporosis is a debilitating condition that affects millions of people worldwide. But can spermidine help osteoporosis? Recent studies suggest this natural compound may offer some promise in preventing and treating the disease. Spermidine has been shown to increase bone density, reduce inflammation, improve cardiovascular health and more.

In this article, we’ll explore what spermidine is, how it affects osteoporosis treatment and prevention, as well as ways you can incorporate it into your diet for better results. So if you’re looking for an alternative way to manage your osteoporosis symptoms or prevent further damage from occurring – read on!

Can spermidine help osteoporosios? Let’s find out together!

Table of Contents:

What is Spermidine?

Spermidine is a polyamine compound found naturally in many foods, including aged cheese, mushrooms, legumes, whole grains and some types of fish. It has been studied for its potential role in promoting longevity and preventing age-related diseases.

Definition: Spermidine is an organic compound made up of three amino acids – cysteine, histidine and methionine – linked together by sulfur bonds. It plays an important role in cell growth and development as well as regulating gene expression.

Sources of Spermidine: Foods that are high in spermidine include aged cheese such as Parmesan or cheddar; mushrooms such as shiitake or portobello; legumes like lentils or chickpeas; whole grains like oats or barley; and certain types of fish such as mackerel or tuna.

Studies have shown that spermidine may help to reduce inflammation, improve cardiovascular health, boost the immune system and protect against cancer. Additionally, it has been suggested that spermidine may be beneficial for those with osteoporosis due to its ability to stimulate bone formation while inhibiting bone resorption (breakdown).

Spermidine is a naturally occurring compound with potential benefits for bone health and osteoporosis management. In the next section, we will explore how spermidine can affect osteoporosis patients.

How Does Spermidine Affect Osteoporosis?

Role of Spermidine in Bone Health

Spermidine has been studied extensively for its potential role in promoting healthy bones. It helps regulate cell growth and division, which are essential processes for maintaining strong bones. Additionally, spermidine also increases collagen production, which helps keep bones flexible and resistant to fractures or breaks.

Potential Benefits for Osteoporosis Patients

Osteoporosis is a condition characterized by low bone density that makes them more prone to fractures or breaks. Research suggests that supplementing with spermidine may help reduce the risk of developing osteoporosis by increasing collagen production and improving overall bone health.

In addition, studies have also suggested that taking spermidine supplements may help slow down the progression of existing osteoporosis symptoms such as reduced mobility due to joint pain or stiffness caused by weakened bones.

Possible Side Effects & Risks

While there is still much to learn about the effects of spermidine on osteoporosis, current research suggests that it may be a promising treatment option for those with the condition. In this section, we will take a closer look at existing clinical studies and their results.

Key Takeaway: Spermidine may be beneficial for osteoporosis patients by helping to reduce bone loss and increase bone density. It helps regulate cell growth and division, increases collagen production, and may slow down the progression of existing osteoporosis symptoms. However, it is important to consult a healthcare professional before taking any supplements as there can be potential side effects or risks associated with them.

Clinical Studies on the Use of Spermidine for Osteoporosis Treatment

Overview of Existing Research Studies: Several clinical trials have investigated the effects of spermidine supplementation on bone health. These studies have generally shown that supplementing with spermidine can increase bone mineral density (BMD) and reduce markers of bone turnover such as collagen cross-links and C-terminal telopeptide (CTX). However, it is important to note that these results are not conclusive due to the small sample sizes used in most studies.

Clinical studies have shown promising results in the use of spermidine for osteoporosis treatment. However, it is important to understand how to properly incorporate this compound into your diet and lifestyle for maximum benefit.

How to Incorporate Spermidine into Your Diet for Osteoporosis Prevention and Treatment?

Spermidine has been studied for its potential role in preventing and treating osteoporosis. Incorporating spermidine into your diet can help improve bone health and reduce the risk of developing osteoporosis.

Recommended Dosage and Timing for Maximum Benefit: The recommended daily dosage of spermidine to benefit from its anti-osteoporotic effects is between 1-3 milligrams per day. To get the most out of this supplement it should be taken with meals or snacks throughout the day rather than all at once.

Foods Rich in Spermidine to Include in Your Diet: There are several food sources that contain high levels of spermidine such as aged cheeses like parmesan or cheddar, mushrooms such as shiitake or oyster mushrooms, legumes like chickpeas or lentils, wheat germ oil and whole grains like oats or barley.

Spermidine Supplements

One of the easiest ways to insure adequate Spermidine intake is to take a daily supplement. Our favorite choices come from a high quality company called Intuitive Nutrients. Two options are available: True-Spermidine™️ capsules combine 3 mgs or Spermidine with 375 mgs of trans-Resveratrol.

And True-Autophagy™️ capsules deliver 6 mgs of Spermidine with 300 mgs of Nicotinamide Mononucleotide (NMN) and 20 mgs of Pyrroloquinoline Quinone (PQQ). Both products deliver the osteoporosis benefits of Spermidine and also the longevity benefits of their other critical ingredients. Find them both at

Other Health Benefits of Spermidine

Because Spermidine is a polyamine, a molecule involved in the most basic genetic functions of our physiology, there is almost no aspect of our health that is not benefitted by health Spermidine levels. These include:

  • DNA Methylation (gene expression)
  • Cardiovascular Health
  • Telomere Length Protection
  • Protects Liver from Alcohol
  • Blood Pressure
  • Caloric Restriction Mimetic (Autophagy Enhancement)
  • Kidney Protective
  • Cancer Protection
  • Immune System Strength (T cells)
  • Mitochondrial Health and Longevity (mitophagy)
  • Hair Growth
  • Wound Healing
  • Cognitive Function (Protection from Dementia)
  • Overall Lifespan
Key Takeaway: Spermidine can help improve bone health and reduce the risk of developing osteoporosis. It also has a vast comprehensive benefit to human health and longevity. Recommended daily dosage is 1-3 mgs, taken with meals or snacks throughout the day. Foods rich in spermidine include: • Aged cheeses • Mushrooms • Legumes • Wheat germ oil • Whole grains


In conclusion, spermidine is a naturally occurring compound found in many foods that has been linked to numerous health benefits. It can be beneficial for people with osteoporosis as it may help reduce bone loss and increase bone density. Clinical studies have shown that spermidine supplementation can improve the symptoms of osteoporosis in some individuals.

Intuitive Nutrients is a leading manufacturer of high quality targeted nutraceuticals. Because spermidine has such great potential for human health across the board, Intuitive Nutrients features spermidine in two of its flagship products: True-Spermidine™️ with added trans-Resveratrol, and True-Autophagy™️ with added NMN (nicotinamide mononucleotide) and PQQ.
Our products contain natural ingredients that have been clinically proven to be effective in treating a variety of conditions, such as fatty liver disease and osteoporosis.  Contact Intuitive Nutrients today for more information on how we can help improve your quality of life with our unique approach!

Dr. Steven Bennett
Dr. Steve Bennett

Intuitive Nutrients

Intuitive Nutrients was started by Dr. Steven Bennett as a way to provide top quality clinical-grade nutrients for his practice, at a reasonable price. Situated in beautiful San Diego Intuitive Nutrients is locally owned and operated by Dr. Bennett, his family and team. And they are proud to dedicate a portion of Intuitive Nutrients' profits to the Surfrider Foundation and Rady Children's Hospital.

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